Nemesio “El Mencho” Oseguera Cervantes, leader of the Jalisco New Generation Cartel and one of the world’s most-wanted drug traffickers, was killed in a Mexican military operation on Sunday in Tapalpa, Jalisco. The raid, supported by information from U.S. authorities, resulted in Oseguera and two others dying from injuries sustained during the mission. Four cartel members were killed at the scene, and three Mexican soldiers were injured. The U.S. State Department urged American tourists in affected areas to shelter in place as violence erupted across multiple states.

Following the operation, suspected cartel members torched buses, blocked roads, and attacked businesses in Jalisco, Michoacán, and Guanajuato. Flights to Puerto Vallarta and Guadalajara were canceled, leaving travelers stranded, though airports later resumed operations. Mexican President Claudia Sheinbaum praised the military’s coordination and said most of the country remained calm. U.S. Deputy Secretary of State Christopher Landau called Oseguera’s death a major development for both nations.

The operation marks a significant security milestone for Mexico amid pressure from the Trump administration to curb drug trafficking, though Sheinbaum has previously warned that targeting cartel leaders can trigger further violence.