Medical experts have raised alarm over the rapid rise of antibiotic resistance, warning that the world could soon enter a post-antibiotic era where even minor infections become deadly. According to data from India’s ICMR and NCDC, common bacteria such as E. coli, Klebsiella, Staphylococcus aureus, and Pseudomonas are increasingly resistant to conventional antibiotics. Dr. Sunil Havannavar of Manipal Hospital explained that misuse and overuse of antibiotics, along with poor infection control, are accelerating the crisis. The World Health Organization (WHO) has identified antibiotic resistance as one of the top ten global health threats. If antibiotics lose effectiveness, surgeries like heart transplants, joint replacements, and cancer chemotherapy will become highly unsafe. Experts emphasize that responsible antibiotic use, public awareness, and systemic healthcare reforms are essential to prevent a catastrophic medical future where modern treatments could fail.