The Alliance for Health Reforms Bangladesh (AHRB) has urged the Chief Adviser to prioritize the implementation of the Active Pharmaceutical Ingredient (API) policy as a matter of national interest. In an open letter signed by Professor Syed Abdul Hamid of Dhaka University and Professor Syed Md. Akram Hossain of Bangabandhu Sheikh Mujib Medical University, the group called for immediate administrative action to reduce import dependency and bolster national health security. The letter highlights that although Bangladesh can produce most types of medicines, it remains heavily reliant on imported APIs, leaving the pharmaceutical supply chain vulnerable to global market disruptions. The AHRB recommended five urgent steps, including a production-linked incentive scheme, sustained R&D funding, stronger academia–industry collaboration, and formation of a permanent task force. Citing the success of the 1982 National Drug Policy, the group emphasized that strong political commitment and leadership are essential. Experts argue that developing a knowledge-based pharmaceutical sector could raise the tax-to-GDP ratio and expand exports. The AHRB warned that without top-level oversight, the API policy may remain unimplemented, hindering Bangladesh’s competitiveness and health resilience.