A UPS cargo plane crashed and exploded shortly after takeoff from Louisville’s Muhammad Ali International Airport in Kentucky on Tuesday evening, killing at least three people and injuring 11 others. Governor Andy Beshear said the numbers are likely to rise as emergency teams continue search and rescue operations amid dangerous conditions. The McDonnell Douglas MD-11 aircraft, built in 1991, was en route to Honolulu when flames erupted on its left wing around 5:15 p.m. Video footage showed the aircraft briefly lifting off before crashing and bursting into a massive fireball. Nearby structures sustained significant damage, including parts of a roof torn off near the runway. Louisville Mayor Craig Greenberg cited the large quantity of jet fuel onboard as a major hazard for responders. Authorities have issued a shelter-in-place order for areas north of the airport up to the Ohio River due to possible toxic fumes. Louisville’s UPS hub, one of the world’s largest package handling facilities, has temporarily suspended operations. Officials urge residents to stay indoors and keep emergency routes clear while investigations continue.