Global health authorities warn that typhoid, once easily treated with antibiotics, is returning in a far more dangerous form. Extensively drug-resistant (XDR) strains, particularly spreading from Pakistan, no longer respond to traditional or even newer antibiotics. In the UK alone, 702 confirmed cases were reported in 2024, an 8% increase from the previous year, mostly among travelers returning from high-risk countries. Research from Stanford University shows that resistant bacteria are rapidly replacing normal strains and spreading internationally. Experts warn that data from Africa and Oceania is limited, suggesting the real scale may be underestimated. Oral antibiotics still work in some cases, but their effectiveness is declining. Health authorities emphasize urgent global surveillance, new treatment development, and vaccination programs to curb this escalating threat. Typhoid is quietly becoming a major global health emergency.
There was a time when typhoid could be stopped with antibiotics. Now, the old disease is making a comeback—and this time, the usual medicines are failing. The bacteria have gradually evolved into a much stronger and more dangerous form, so much so that antibiotics are now largely ineffective.
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