More than 2,000 senior officials at NASA are resigning amid proposed budget cuts, risking a major loss of expertise crucial for upcoming space missions. The departures, including scientists, engineers, and mission planners, may disrupt plans for sending humans to the Moon and Mars. Layoffs are ongoing across NASA’s centers, with Goddard, Johnson, and Kennedy centers most affected. Experts warn this could weaken U.S. leadership in space exploration, especially as complex missions approach. The workforce may shrink to its smallest since the 1960s.