Iran has denounced ongoing nuclear negotiations with the United States as pointless after Israeli airstrikes killed top Iranian military leaders and nuclear scientists. Iran’s Foreign Ministry accused Washington of enabling the attacks by Israel, saying that such actions contradict the spirit of diplomacy. The scheduled sixth round of nuclear talks in Muscat now faces uncertainty. The deadly strikes led to the confirmed deaths of General Hossein Salami and General Mohammad Bagheri. Tehran has since retaliated by launching missile attacks on Tel Aviv.

Iran launched multiple ballistic missiles at Israel on Friday night and early Saturday in retaliation for Israeli airstrikes, killing at least three people and injuring about 80. While Iranian media claimed hundreds of missiles were fired, Israeli defense sources said the real number was under 100 and most were intercepted before impact.

Major General Amir Hatami has been appointed the new Commander-in-Chief of Iran’s army by Supreme Leader Ayatollah Ali Khamenei. Hatami previously served as Iran’s Defense Minister from 2013 to 2021. In a statement, Khamenei expressed gratitude to outgoing commander Major General Seyyed Abdolrahim Mousavi for his dedication and service.

After Israel’s attack on Iran, global reactions poured in. Iranian President Masoud Pezeshkian warned of a strong and regret-inducing response. Former US President Donald Trump urged both sides to stop the bloodshed, stressing that Iran must never acquire nuclear weapons and suggesting a return to diplomacy. Kremlin spokesman Dmitry Peskov condemned Israel’s actions as “unacceptable and provocative.” China also urged all parties to de-escalate and contribute to regional peace, while the EU emphasized diplomatic solutions.

Iran’s Ambassador to the United Nations, Amir Saeed Iravani, has strongly condemned Israel’s recent strikes on Iran’s nuclear facilities. Speaking at an emergency UN Security Council session, Iravani expressed gratitude to Algeria, Pakistan, China, and Russia for supporting the call for this urgent meeting. Describing Israel as a source of instability in the Middle East, he urged global efforts to rid the region of weapons of mass destruction. Iravani accused Israel’s aggression of being deliberate, systematic, and fully backed by the United States. “There is no doubt about America’s direct involvement in these terrorist attacks,” he added.

Indian Prime Minister Narendra Modi announced via X (formerly Twitter) that he had spoken with Israeli Prime Minister Benjamin Netanyahu to express India’s concerns over the escalating conflict. Modi emphasized the urgent need to restore peace and stability in the region. Netanyahu’s office confirmed that the Israeli leader has been holding talks with several world leaders, including the German Chancellor, French President, and Indian Prime Minister, with further calls planned with U.S., Russian, and UK leaders.

As debates over the U.S. role in the escalating Israel-Iran conflict intensify, former U.S. President Donald Trump finds himself in an increasingly complicated and politically risky position, reports BBC’s White House correspondent Gary O’Donoghue. While U.S. Secretary of State Marco Rubio tried to distance the administration from Israel’s offensive, labeling it a “unilateral Israeli decision,” Trump later praised the attack as “excellent” and lauded the “extraordinary American technology” used. This contrasts with Trump’s earlier promises of “ending wars, not starting new ones.”

Iran’s semi-official Mehr News Agency has claimed that Iranian forces shot down two Israeli fighter jets during the latest round of hostilities. One of the downed aircraft reportedly had a female pilot, who has allegedly been taken into custody, according to Tasnim News. However, the Israeli military has firmly denied these claims, stating that no Israeli aircraft have been shot down and no personnel are missing or captured.

Amid escalating tensions between Israel and Iran, Saudi Crown Prince Mohammed bin Salman and former U.S. President Donald Trump held a phone conversation on Friday, discussing the regional security situation. Both leaders expressed deep concern over the unfolding crisis and stressed the need for maximum restraint and a diplomatic resolution. Meanwhile, UN Secretary-General António Guterres has called on both Israel and Iran to de-escalate immediately.

Iran has launched another attack targeting Israel, with powerful explosions reported in Tel Aviv and occupied Jerusalem around midnight on Saturday. Following the attack, Israeli authorities instructed civilians and military personnel to take immediate shelter until further notice. Footage shared by Reuters shows smoke rising in Tel Aviv after what appears to be a missile strike. Reports suggest that Iran's president and supreme leader have personally designated Israel as their direct target.

In a single morning strike, Israel reportedly killed 10 key Iranian figures, severely impacting Iran’s defense and nuclear programs. The casualties include:

General Hossein Salami, Commander-in-Chief of Iran’s Revolutionary Guard Corps

General Gholamali Rashid, Deputy Chief of Armed Forces

Fereydoon Abbasi, Former Head of Iran’s Atomic Energy Organization, nuclear physicist

Mohammad Mehdi Tehranchi, President of Islamic Azad University

Abdul Hamid Minuchehr, Dean of Nuclear Engineering at Shahid Beheshti University

Ahmad Reza Zolfaghari, Professor of Nuclear Engineering at Shahid Beheshti University

Amir Hossein Faghihi, Former Vice President of Iran’s Atomic Energy Organization

Motalebzadeh, a prominent nuclear scientist, killed along with his wife

The Israeli military has reported that a missile was fired from Yemen toward Israeli airspace. Air raid sirens were activated in Jerusalem, triggering panic as residents rushed to nearby shelters. No immediate reports of casualties or damages have been confirmed so far.

Following the death of IRGC Commander-in-Chief General Hossein Salami in Israel’s recent airstrikes, Iran’s Supreme Leader Ayatollah Ali Khamenei has appointed Major General Mohammad Pakpour as the new chief of the Islamic Revolutionary Guard Corps (IRGC), according to Al Jazeera. The IRGC serves as a military, political, and economic pillar of Iran’s Islamic regime, tasked with countering threats from both within and outside the country. It also plays a key role in overseeing Iran’s nuclear program and regional military operations.

Multiple Iranian news outlets are reporting that Israeli strikes across several regions of Iran have killed at least 78 people and injured 329. The Iranian government has not yet released official casualty figures. Reports claim the attacks have killed several key figures, including the head of Iran’s Revolutionary Guard, the chief of the armed forces, and several prominent nuclear scientists. In retaliation, Iran has launched counterattacks targeting Israel.

Following coordinated attacks on eight Iranian cities early Friday, Israel has reportedly launched a fresh round of airstrikes targeting Shiraz and Tabriz. Additionally, fresh strikes have hit the Natanz nuclear facility, according to Iranian media reports. Iran’s Tasnim News Agency reported multiple explosions near Tabriz Airport, while state television confirmed new blasts in East Azerbaijan province minutes before the latest update. Israel has yet to issue an official statement on this fresh offensive.